The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for ChlorpyrifosDecreased body weight in adutlhood at 1 mg/kg |
Subjects: Sprague-Dawley rats Chemical: Chlorpyrifos Low doses tested: 1.0, 2.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5) Age of measurement: gestational day 21 and post-natal day 60 |
Reference [PubMed Link] Meyer A, Seidler FJ, Slotkin TA. 2004. Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect 112(2):170-178. |
| Study Results | Study Details | References |
Results for ChlorpyrifosDecreased heart weight in adulthood at 1 mg/kg; increased Beta-adrenergic receptor binding in the heart at gestational day 21 at 1 and 2 mg/kg; increased adenylyl cyclase basal activity in the heart at gestational day 21 at 1 and 2 mg/kg; decreased adenylyl cyclase activity stimulated by isoproterenol in the heart at gestational day 21 at 5 mg/kg; increased adenyly cyclase activity stimulated by Mn2+ in the heart at gestational day 21 at all doses; increased total induced activity of adenylyl cyclase in the heart of males at post-natal day 60 at 1 mg/kg |
Subjects: Sprague-Dawley rats Chemical: Chlorpyrifos Low doses tested: 1.0, 2.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5) Age of measurement: gestational day 21 and post-natal day 60 |
Reference [PubMed Link] Meyer A, Seidler FJ, Slotkin TA. 2004. Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect 112(2):170-178. |
| Study Results | Study Details | References |
Results for ChlorpyrifosIncreased DNA content; increased m2-AChRs at 1 mg/kg at gestational day 21; decreased m2-AChRs at 5 mg/kg at gestational day 21 |
Subjects: Sprague-Dawley rats Chemical: Chlorpyrifos Low doses tested: 1.0, 2.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5) Age of measurement: gestational days 17 and 21 |
Reference [PubMed Link] Qiao D, Seidler FJ, Padilla S, Slotkin TA. 2002. Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period? Environ Health Perspect 110(11):1097-1103. |
| Study Results | Study Details | References |
Results for ChlorpyrifosIncreased DNA content measured at gestational day 17; decreased DNA content at gestational day 21; decreased protein/DNA ratio at 2 and 5 mg/kg measured at gestational day 17; increased protein/DNA ratio at 2 and 5 mg/kg at gestational day 21 |
Subjects: Sprague-Dawley rats Chemical: Chlorpyrifos Low doses tested: 1.0, 2.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5) Age of measurement: gestational days 17 and 21 |
Reference [PubMed Link] Qiao D, Seidler FJ, Padilla S, Slotkin TA. 2002. Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period? Environ Health Perspect 110(11):1097-1103. |
| Study Results | Study Details | References |
Results for ChlorpyrifosDecreased body weight of females across adolescence and adulthood |
Subjects: Sprague-Dawley rats Chemical: Chlorpyrifos Low doses tested: 1.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5) Age of measurement: post-natal day 30 and 60 |
Reference [PubMed Link] Qiao D, Seidler FJ, Abreu-Villaca Y, Tate CA, Cousins MM, Slotkin TA. 2004. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Developmental Brain Research 148(1):43-52. |
| Study Results | Study Details | References |
Results for ChlorpyrifosIncreased incidence of dismorphogenesis at 5 μg/ml |
Subjects: Sprague-Dawley rats Chemical: Chlorpyrifos Low doses tested: 0.5 or 5 μg/ml Other doses tested: 50 μg/ml Route of administration: dissolved in media with DMSO in vitro Exposure duration: gestational day 9.5 – gestational day 11.5 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 4) Age of measurement: gestational day 11.5 |
Reference [PubMed Link] Roy TS, Andrews JE, Seidler FJ, Slotkin TA. 1998. Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos. Teratology 58(2):62-68. |
| Study Results | Study Details | References |
Results for ChlorpyrifosIncreased norepinephrine levels at 1.0 and 5.0 mg/kg treatment levels |
Subjects: Sprague Dawley rats Chemical: Chlorpyrifos Low doses tested: 1.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5) Age of measurement: post-natal day 30 |
Reference [PubMed Link] Seidler FJ, Slotkin TA. 2011. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids. Brain Res Bull 85(3-4):225-230. |
| Study Results | Study Details | References |
Results for ChlorpyrifosIncreased norepinephrine levels at 1.0 and 5.0 mg/kg treatment levels |
Subjects: Sprague Dawley rats Chemical: Chlorpyrifos Low doses tested: 1.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5) Age of measurement: post-natal day 30 |
Reference [PubMed Link] Seidler FJ, Slotkin TA. 2011. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids. Brain Res Bull 85(3-4):225-230. |