The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Decreased aromatase activity in males at 1 but not 22 days old; increased aromatase activity in females at 22 days but not 1 day old |
Subjects: Wistar rats Chemical: Phthalates (DEHP) Low doses tested: 0.015, 0.045, 0.135, 0.405 or 1.215 mg/kg bw/d Other doses tested: 5, 15, 45, 135 or 405 mg/kg bw/d Route of administration: dissolved in peanut oil and delivered through gavage Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth) Age of measurement: 1 and 22 days of age |
Reference [PubMed Link] Andrade AJM, Grande SW, Talsness CE, Grote K, Chahoud I. 2006. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): Non-monotonic dose-response and low dose effects on rat brain aromatase activity. Toxicology 227(3):185-192. |
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Increased serum testosterone concentration at 0.045 and 0.405 mg/kg |
Subjects: Wistar rats Chemical: Phthalates (DEHP) Low doses tested: 0.015, 0.045, 0.135, 0.405 or 1.215 mg/kg bw/d Other doses tested: 5, 15, 45, 135 or 405 mg/kg bw/d Route of administration: dissolved in peanut oil and delivered through gavage Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth) Age of measurement: 144 days of age |
Reference [PubMed Link] Andrade AJ, Grande SW, Talsness CE, Gericke C, Grote K, Golombiewski A, Sterner-Kock A, Chahoud I. 2006. A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Reproductive effects on adult male offspring rats. Toxicology 228(1):85-97. |