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The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased number and density of nodules.

Subjects: Fetal calvaria cells of rats

Chemical: Dioxin (TCDD)

Low doses tested: 10 nM

Route of administration: in vitro culture

Exposure duration: gestational day 21 – in vitro culture (comparable to human prenatal development from approximately day 1 of week 15 to day 1 of week 18)

Age of measurement: 6, 8, 10 and 21 days in culture

Reference [PubMed Link]
Gierthy JF, Silkworth JB, Tassinari M, Stein GS, Lian JB. 1994. 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits differentiation of normal diploid rat osteoblasts in vitro. J Cell Biochem 54(2):231-238.