The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Phthalates (DEHP)Decreased testis and seminal vesicle weights. Changes in the developmental capacity of gametes. Decreased sperm count and viability. Decreased LHR and FSHR in the testis.
Subjects: CD-1 mice
Chemical: Phthalates (DEHP)
Low doses tested: 0.05 mg/kg bw/d
Other doses tested: 5.0 mg/kg bw/d
Route of administration: delivered in diet daily
Exposure duration: gestational day 0 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)
Age of measurement: post-natal days 21-42
|Reference [PubMed Link]
Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. 2012. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology 153(2):937-948.