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The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for PFAS (PFOA)

Decreased mammary gland developmental scores marked by reduced ductal elongation and branching including delays in timing and density of terminal end buds.

Subjects: CD-1 mice

Chemical: PFAS (PFOA)

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 7 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 9)

Age of measurement: post-natal days 29, 32 and 18 months

Reference [PubMed Link]
White SS, Kato K, Jia LT, Basden BJ, Calafat AM, Hines EP, Stanko JP, Wolf CJ, Abbott BD, Fenton SE. 2009. Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures. Reprod Toxicol 27(3-4):289-298.