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The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

In superior cervical ganglia neurons: decreased axonal growth rate and length; enhanced BMP-7-induced dendritic growth and increased dendritic length. No affect on AChE activity at doses producing these effects.

Subjects: Holtzmann rats

Chemical: Chlorpyrifos

Low doses tested: 0.0001 to 10 μM

Route of administration: dissolved in DMSO and delivered in vitro

Exposure duration: gestational day 20 – post-natal day 1 (comparable to human prenatal development from approximately day 1 of week 13 to day 1 of week 21)

Age of measurement: in vitro after 24 or 72 hours in treatment culture

Reference [PubMed Link]
Howard AS, Bucelli R, Jett DA, Bruun D, Yang D, Lein PJ. 2005 Sep 1. Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicol Appl Pharmacol 207(2):112-124.