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The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Bisphenol A

Increased glutamate-induced CA3 neuronal damage (not mediated through estrogen receptors); when dosed with 0.001 μM, also increased expression of N-methyl-D-aspartate receptor in CA3, upregulated the spine density of the apical portion of CA3 dendrites and enhanced the sprouting of mossy fiber terminals to CA3 neurons

Subjects: Wistar rat fetal hippocampal cells

Chemical: Bisphenol A

Low doses tested: 1 pM, 1 nM, 1 μM or 100 μM

Route of administration: dissolved in ethanol and added to culture media

Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11)

Age of measurement: in vitro at 20 days post-fertilization

Reference [PubMed Link]
Sato K, Matsuki N, Ohno Y, Nakazawa K. 2002. Effects of 17beta-estradiol and xenoestrogens on the neuronal survival in an organotypic hippocampal culture. Neuroendocrinology 76(4):223-234.