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1 result for: Chlorpyrifos, Immune System — WEEK 31

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Chlorpyrifos

Decreased mitogenic response of T-cells on post-natal day 60 across two doses of concanavalin A

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 31 to day 1 of week 35)

Age of measurement: post-natal day 60

 Reference [PubMed Link]
Navarro HA, Basta PV, Seidler FJ, Slotkin TA. 2001. Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect? Developmental Brain Research 130(2):249-252.