References popup

2 results for: Chlorpyrifos, Immune System — WEEK 20

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Chlorpyrifos

Decreased mitogenic response of T-cells on post-natal day 60 across two doses of concanavalin A

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 1 – post-natal day 4 (comparable to human prenatal development from approximately day 1 of week 20 to day 1 of week 25)

Age of measurement: post-natal day 5 and 60

 Reference [PubMed Link]
Navarro HA, Basta PV, Seidler FJ, Slotkin TA. 2001. Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect? Developmental Brain Research 130(2):249-252.
Study Results Study Details References

Results for Chlorpyrifos

Increased lipid peroxidation at 1.0 and 1.35 mg/kg; decreased superoxide dismutase and glutathione-s-transferase at 1.35 mg/kg; (all measures of oxidative stress).

Subjects: Wistar rats

Chemical: Chlorpyrifos

Low doses tested: 0.01, 1.0 or 1.35 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered via oral gavage

Exposure duration: post-natal day 1 – post-natal day 20 (comparable to human prenatal development from approximately day 1 of week 20 to beyond birth)

Age of measurement: post-natal day 21

 Reference [PubMed Link]
Mansour SA, Mossa AH. 2010. Adverse effects of lactational exposure to chlorpyrifos in suckling rats. Human & Experimental Toxicology 29(2):77-92.