The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for ChlorpyrifosIncreased lose-shift errors in T-maze delayed-alternation task in both males and females treated gestationally with 5.0 mg/kg. With a gradual increase in the number of errors in males at the longest delay time of 60 seconds. |
Subjects: ICR mice Chemical: Chlorpyrifos Low doses tested: 1.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 13 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 9) Age of measurement: post-natal day 45 through post-natal day 60 |
Reference [PubMed Link] Chen XP, Chen WZ, Wang FS, Liu JX. 2012. Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure. Brain Res 1474:19-28. |
| Study Results | Study Details | References |
Results for ChlorpyrifosDecreased number of cells in Prl and IL regions of the medial prefrontal cortex in both males and females treated with 5.0 mg/kg. |
Subjects: ICR mice Chemical: Chlorpyrifos Low doses tested: 1.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 13 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 9) Age of measurement: post-natal day 45 through post-natal day 60 |
Reference [PubMed Link] Chen XP, Chen WZ, Wang FS, Liu JX. 2012. Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure. Brain Res 1474:19-28. |
| Study Results | Study Details | References |
Results for ChlorpyrifosDecreased number of cells in CA1, DG, and CA3 regions of the dorsal hippocampus in males and in the DG in females treated with 5.0 mg/kg. |
Subjects: ICR mice Chemical: Chlorpyrifos Low doses tested: 1.0 or 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 13 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 9) Age of measurement: post-natal day 45 through post-natal day 60 |
Reference [PubMed Link] Chen XP, Chen WZ, Wang FS, Liu JX. 2012. Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure. Brain Res 1474:19-28. |
| Study Results | Study Details | References |
Results for ChlorpyrifosDecreased dopamine levels in the cerebral cortex on post-natal days 14 and 60 |
Subjects: ICR mice Chemical: Chlorpyrifos Low doses tested: 5.0 mg/kg bw/d Route of administration: dissolved in DMSO and injected subcutaneously Exposure duration: gestational day 13 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 9) Age of measurement: gestational day 17 and post-natal days 14 and 60 |
Reference [PubMed Link] Chen XP, Wang X, Dong JY. 2011. Different reaction patterns of dopamine content to prenatal exposure to chlorpyrifos in different periods. J Appl Toxicol 31(4):355-359. |