The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Increased serum testosterone levels in males treated with 0.5, 5.0, and 500.0 μg/kg |
Subjects: CD-1 mice Chemical: Phthalates (DEHP) Low doses tested: 0.5, 1.0, 5.0, and 500.0 μg/kg bw/d Other doses tested: 50000.0, 500,000.0 μg/kg bw/d Route of administration: dissolved in tocopherol-stripped corn oil and administered orally Exposure duration: gestational day 9 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 11) Age of measurement: gestational day 18 |
Reference [PubMed Link] Do RP, Stahlhut RW, Ponzi D, Vom Saal FS, Taylor JA. 2012. Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod Toxicol 34(4):614-621. |
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Increased serum testosterone levels in males treated with 0.5, 5.0, and 500.0 μg/kg |
Subjects: CD-1 mice Chemical: Phthalates (DEHP) Low doses tested: 0.5, 1.0, 5.0, and 500.0 μg/kg bw/d Other doses tested: 50000.0, 500,000.0 μg/kg bw/d Route of administration: dissolved in tocopherol-stripped corn oil and administered orally Exposure duration: gestational day 9 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 11) Age of measurement: gestational day 18 |
Reference [PubMed Link] Carr RL, Borazjani A, Ross MK. 2011. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol Sci 122(1):112-120. |