The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Increased escape latency and decreased time spent in removed quadrant on the Morris water-maze test. |
Subjects: Sprague Dawley rats Chemical: Phthalates (DEHP) Low doses tested: 1.25 mg/kg bw/d Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 2 – gestational day 21 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 16) Age of measurement: 19, 21 and 22 months |
Reference [PubMed Link] Sun W, Ban JB, Zhang N, Zu YK, Sun WX. 2012 May 19 (in press). Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environ Toxicol . |
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Alterations in the expression of hippocampal insulin, IGF-I, IGF-II, bim, bad, p-GSK-3β, and p-Akt. Increased levels of phosphorylated tau in the hippocampus. |
Subjects: Sprague Dawley rats Chemical: Phthalates (DEHP) Low doses tested: 1.25 mg/kg bw/d Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 2 – gestational day 21 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 16) Age of measurement: 19, 21 and 22 months |
Reference [PubMed Link] Sun W, Ban JB, Zhang N, Zu YK, Sun WX. 2012 May 19 (in press). Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environ Toxicol . |