The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased body weight at some doses and time points with results varying by sex |
Subjects: Holtzman rats Chemical: Dioxin (TCDD) Low doses tested: 0.02, 0.6 or 0.18 μg/kg Route of administration: dissolved in olive oil and delivered through gavage Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9) Age of measurement: birth through young adulthood |
Reference [PubMed Link] Markowski VP, Zareba G, Stern S, Cox C, Weiss B. 2001. Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 109(6):1-7. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased mortality at day 1 after birth |
Subjects: Holtzman rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9) Age of measurement: birth through adulthood |
Reference [PubMed Link] Flaws JA, Sommer RJ, Silbergeld EK, Peterson RE, Hirshfield AN. 1997. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces genital dysmorphogenesis in the female rat. Toxicology & Applied Pharmacology 147(2):351-362. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased weights in treated males at 60 days of age |
Subjects: Dark-Agouti rats Chemical: Dioxin (TCDD) Low doses tested: 0.7 μg/kg bw Route of administration: dissolved in corn oil and administered orally Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9) Age of measurement: post-natal days 1, 14 and 60 |
Reference [PubMed Link] Tomasini MC, Beggiato S, Ferraro L, Tanganelli S, Marani L, Lorenzini L, Antonelli T. 2012. Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex. Neurochem Int 61(5):759-766. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Reduced litter size and decreased number of females in litters |
Subjects: Dark-Agouti rats Chemical: Dioxin (TCDD) Low doses tested: 0.7 μg/kg bw Route of administration: dissolved in corn oil and administered orally Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9) Age of measurement: post-natal days 1, 14 and 60 |
Reference [PubMed Link] Tomasini MC, Beggiato S, Ferraro L, Tanganelli S, Marani L, Lorenzini L, Antonelli T. 2012. Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex. Neurochem Int 61(5):759-766. |