The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative thymus weight at 67 days of age with in utero only exposure |
Subjects: C57BL/6N mice Chemical: Dioxin (TCDD) Low doses tested: 3.0 μg/kg bw Other doses tested: 12.0μg/kg Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 6 and cross-fostered at birth – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3) Age of measurement: birth through 67 days of age |
Reference [PubMed Link] Couture-Haws L, Harris MW, Lockhart AC, Birnbaum LS. 1991. Evaluation of the persistence of hydronephrosis induced in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 107(3):402-412. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased thymic weight at gestational day 18; decreased thymic cellularity (cell yield per thymus) at gestational day 18 and at 6 days of age; significantly altered patterns of thymocyte expression of cell surface antigens CD4 and CD8 at gestational day 18 and 6 days of age but not 14 days of age; depressed cytotoxic T lymphocyte activity at 8 weeks of age |
Subjects: C57BL/6N mice Chemical: Dioxin (TCDD) Low doses tested: 1.5 or 3.0 μg/kg bw/d Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 6 – gestational day 14 (and cross fostered after birth) (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth) Age of measurement: gestational day 18 and post-natally through 10 weeks of age |
Reference [PubMed Link] Holladay SD, Lindstrom P, Blaylock BL, Comment CE, Germolec DR, Heindell JJ, Luster MI. 1991. Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD). Teratology 44(4):385-393. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased CD4-8- and CD4-8+ thymocytes; decreased CD4+8+ thymocytes; decreased TCRαβ and increased TCRγδ at higher dose; decrease in small cell population with relative increase in larger (less mature) cells |
Subjects: B6C3F1 mice Chemical: Dioxin (TCDD) Low doses tested: 1.5 or 3.0 μg/kg bw/d Route of administration: not specified Exposure duration: gestational day 6 – gestational day 14 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 11) Age of measurement: gestational day 18 |
Reference Luster MI, Holladay SD, Blaylock BL, Germolec DR, Clark GC, Comment CE, Heindel JJ, Rosenthal GJ. 1992. TCDD inhibits murine thymocyte and B lymphocyte maturation. Chemosphere 25(1-2):115-118. |