The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative spleen weight for males at 0.0056 μg/kg; increased number of bacteria in female spleen 2 days after intraperitoneal injection with Listeria monocytogenes |
Subjects: C57BL/6NCji mice Chemical: Dioxin (TCDD) Low doses tested: 0.00057 or 0.0056 μg/kg bw, total in 17 daily doses Route of administration: dissolved in drinking water Exposure duration: birth – 21 days of age (comparable to human prenatal development from approximately day 1 of week 13 to beyond birth) Age of measurement: 21 days of age |
Reference [PubMed Link] Sugita-Konishi Y, Kobayashi K, Naito H, Miura K, Suzuki Y. 2003. Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem 67(1):89-93. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased number of CD4 positive thymus cells in males at 0.0056 μg/kg |
Subjects: C57BL/6NCji mice Chemical: Dioxin (TCDD) Low doses tested: 0.00057 or 0.0056 μg/kg bw, total in 17 daily doses Route of administration: dissolved in drinking water Exposure duration: birth – 21 days of age (comparable to human prenatal development from approximately day 1 of week 13 to beyond birth) Age of measurement: 21 days of age |
Reference [PubMed Link] Sugita-Konishi Y, Kobayashi K, Naito H, Miura K, Suzuki Y. 2003. Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem 67(1):89-93. |