The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased testosterone concentration at highest dose in adulthood |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.025, 0.060, 0.3 μg/kg bw Other doses tested: Initial dose was followed by weekly maintenance doses (at 20 percent) Route of administration: injected subcutaneously Exposure duration: pre-conception – post-natal day 22 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: birth through adulthood |
Reference [PubMed Link] Faqi AS, Chahoud I. 1998. Antiestrogenic effects of low doses of 2,3,7,8-TCDD in offspring of female rats exposed throughout pregnancy and lactation. Bulletin of Environmental Contamination & Toxicology 61(4):462-469. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased level of ovalbumin (OVA) - specific immunoglobulin G and E (IgG and IgE) in plasma of adult offspring |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw on gestational days 0, 7, and 14 and at 2 days of age Route of administration: dissolved in peanut oil and delivered through gavage Exposure duration: gestational day 0 (cross-fostered at 2 days of age) – last dose at 2 days of age (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: eight through 10 weeks of age |
Reference [PubMed Link] Hogaboam JP, Moore AJ, Lawrence BP. 2008 Mar. The aryl hydrocarbon receptor affects distinct tissue compartments during ontogeny of the immune system. Toxicol Sci 102(1):160-70. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased levels of FSH and LH in the F2 and F3 generations and decreased E2 levels in the F1 and F3 generations in females. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 2.0 ng/L Route of administration: dissolved in DMSO and delivered in drinking water Exposure duration: gestational day 0 – daily in drinking water (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: post-natal day 1, 4, 21, and 35 |
Reference [PubMed Link] Huang L, Huang R, Ran XR, Liu HY, Zhang Y, Dai LJ, Li B. 2011. Three-generation experiment showed female C57BL/6J mice drink drainage canal water containing low level of TCDD-like activity causing high pup mortality. J Toxicol Sci 36(6):713-724. |