The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased expression of testicular steroid acute regulatory protein (StAR) mRNA at 0.2μg/kg; increased diameter of infant testis seminiferous cord at 0.04 μg/kg |
Subjects: Sprague-Dawley rats Chemical: Dioxin (TCDD) Low doses tested: 0.04, 0.20, or 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 13 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: 14 days of age |
Reference [PubMed Link] Haavisto TE, Myllymaki SA, Adamsson NA, Brokken LJS, Viluksela M, Toppari J, Paranko J. 2006. The effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on testicular steroidogenesis in infantile male rats. Int J Androl 29(2):313-322. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased relative testis weight at 1.0 μg/kg at 12 days of age and at 0.2 μg/kg at 14 days of age |
Subjects: Sprague-Dawley rats Chemical: Dioxin (TCDD) Low doses tested: 0.04, 0.2 or 1.0 μg/kg bw Route of administration: dissolved in corn oil, sonicated, and delivered via gavage Exposure duration: gestational day 13 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: 10 through 16 days of age |
Reference [PubMed Link] Myllymaki SA, Haavisto TE, Brokken LJS, Viluksela M, Toppari J, Paranko J. 2005. In utero and lactational exposure to TCDD; Steroidogenic outcomes differ in male and female rat pups. Toxicol Sci 88(2):534-544. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased number of anterior-dorsolateral and ventral prostatic buds in different regions of the urogenital sinus in C57BL/6J and TGF-α (-/-) strains of mice on GD 17.5 for 1.0 and 5.0 μg/kg bw |
Subjects: C57BL/6J and other mice Chemical: Dioxin (TCDD) Low doses tested: 0.2, 1.0, or 5μg/kg bw Other doses tested: 10, 50, 100 or 150 μg/kg bw Route of administration: delivered through gavage Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: gestational day 17.5 |
Reference [PubMed Link] Abbott BD, Lin TM, Rasmussen NT, Albrecht RM, Schmid JE, Peterson RE. 2003. Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD. Toxicol Sci 76(2):427-436. |