The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased ano-genital distance/body length on post-natal day 30 |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and administered orally Exposure duration: post-natal day 1 – post-natal day 4 (comparable to human prenatal development from approximately day 1 of week 15 to day 1 of week 21) Age of measurement: post-natal days 7, 21, 30 and 60 |
Reference [PubMed Link] Jin MH, Hong CH, Lee HY, Kang HJ, Han SW. 2010. Toxic effects of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on development of male reproductive system: involvement of antioxidants, oxidants, and p53 protein. Environ Toxicol 25(1):1-8. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative testes and epididymal weights on post-natal day 60. Decreased sperm count on post-natal day 60 and decreased testosterone, SOD, CAT, and GR activity with increased H2O2 levels on post-natal days 30 and 60. Increased testicular p53 and Bax on post-natal days 30 and 60. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and administered orally Exposure duration: post-natal day 1 – post-natal day 4 (comparable to human prenatal development from approximately day 1 of week 15 to day 1 of week 21) Age of measurement: post-natal days 7, 21, 30 and 60 |
Reference [PubMed Link] Jin MH, Hong CH, Lee HY, Kang HJ, Han SW. 2010. Toxic effects of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on development of male reproductive system: involvement of antioxidants, oxidants, and p53 protein. Environ Toxicol 25(1):1-8. |