The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased uterine horn weight |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 3.0 μg/kg/bw Other doses tested: 0, 3, or 10 μg/kg/bw at 77 days of age, again 21 days later at time of surgery, and at intervals 3, 6, and 9 weeks after surgery Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 8 – adulthood (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth) Age of measurement: birth through adulthood |
Reference [PubMed Link] Cummings AM, Hedge JM, Birnbaum LS. 1999. Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice. Toxicol Sci 52(1):45-49. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased frequency of cleft clitoris and vaginal thread |
Subjects: Holtzman rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 11 – single dose (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 4) Age of measurement: birth through adulthood |
Reference [PubMed Link] Flaws JA, Sommer RJ, Silbergeld EK, Peterson RE, Hirshfield AN. 1997. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces genital dysmorphogenesis in the female rat. Toxicology & Applied Pharmacology 147(2):351-362. |