The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased urethral slit; decreased urethral-vaginal distance; increased cyctic hyperplasia of the endometrium; increased inflammatory lesions of the cervix |
Subjects: Long Evans hooded rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3) Age of measurement: birth through adulthood |
Reference [PubMed Link] Gray LE, Kelce WR, Monosson E, Ostby JS, Birnbaum LS. 1995. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicology & Applied Pharmacology 131(1):108-118. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased incidence of constant estrous by middle age (about 1 year old); decreased fertility |
Subjects: Long Evans hooded rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3) Age of measurement: birth through adulthood |
Reference [PubMed Link] Gray LE, Kelce WR, Monosson E, Ostby JS, Birnbaum LS. 1995. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicology & Applied Pharmacology 131(1):108-118. |