The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased percentage of eyes opened at 11 through 15 days of age |
Subjects: Line C (highly sensitive to TCDD) rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered orally Exposure duration: gestational day 13 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: 40 days of age |
Reference [PubMed Link] Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased expression of insulin-like growth factor binding protein 5 (IGFBP5) mRNA |
Subjects: C57BL/6J mice Chemical: Dioxin (TCDD) Low doses tested: 5.0 μg/kg Route of administration: dissolved in corn oil and delivered orally Exposure duration: gestational day 12.5 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: gestational day 18.5 |
Reference [PubMed Link] Tanaka J, Yonemoto J, Zaha H, Kiyama R, Sone H. 2007. Estrogen-responsive genes newly found to be modified by TCDD exposure in human cell lines and mouse systems. Molecular & Cellular Endocrinology 272(1-2):38-49. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased whole brain mRNA levels of Cyp1b1, Cxcl4, and Cxcl7 at various time points in both males and females with mRNA decreases in Cxcl5 and Ccl22. |
Subjects: C57BL/6N mice Chemical: Dioxin (TCDD) Low doses tested: 5.0 μg/kg bw Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 12.5 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: gestational days 15.5 and 18.5 and on post-natal days 1, 5 and 21 |
Reference [PubMed Link] Mitsui T, Taniguchi N, Kawasaki N, Kagami Y, Arita J. 2011. Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain. J Appl Toxicol 31(3):279-284. |