The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased percentage with onset of eye opening at 15 days of age; increased successful righting reflex at 5 and 6 days of age; increased successful cliff-drop aversion reflex at 7 days of age at higher dose; decreased ability to stay on a rotating rod |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 1.0 μg/kg bw Other doses tested: Initial dose was followed by weekly maintenance doses (at 40 percent) Route of administration: injected subcutaneously Exposure duration: gestational day 19 – adulthood (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth) Age of measurement: birth through adulthood |
Reference [PubMed Link] Thiel R, Koch E, Ulbrich B, Chahoud I. 1994. Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin - effects on physiological development, reflexes, locomotor activity and learning behaviour in Wistar rats. Arch Toxicol 69(2):79-86. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased percentage of eyes opened at 12 through 15 days of age |
Subjects: Line C (highly sensitive to TCDD) rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered orally Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11) Age of measurement: 40 days of age |
Reference [PubMed Link] Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased (delayed) eye opening at 15 days of age |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 1.0 μg/kg bw initial dose, with 0.4 or 0.12 μg/kg weekly maintenance doses Route of administration: injected subcutaneously Exposure duration: gestational day 19 – at 5 weeks of age (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth) Age of measurement: 7 through 31 days of age |
Reference Thiel R, Korte M, Chahoud I, Neubert D. 1992. Locomotor-activity and postnatal-development of rats after exposure to 2,3,7,8-TCDD during the late fetal and early postnatal-period. Chemosphere 25(7-10):1227-1231. |