References popup

2 results for: Bisphenol A, Male Reproductive System — WEEK 6

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Increased expression of platelet-derived growth factor receptors α and β mRNA in whole testis at 1.0 mg/kg bw/d and higher doses

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 0.1 or 1.0 mg/kg bw/d

Other doses tested: 10 or 200 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 14 – post-natal day 0 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 20)

Age of measurement: 3 days of age

 Reference [PubMed Link]
Thuillier R, Wang Y, Culty M. 2003. Prenatal exposure to estrogenic compounds alters the expression pattern of platelet-derived growth factor receptors alpha and beta in neonatal rat testis: Identification of gonocytes as targets of estrogen exposure. Biol Reprod 68(3):867-880.
Study Results Study Details References

Results for Bisphenol A

Increased number and volume of ducts due to increased proliferation of basal epithelial cells; also malformed urethra

Subjects: CD-1 mice

Chemical: Bisphenol A

Low doses tested: 10 μg/kg bw/d

Route of administration: dissolved in corn oil and fed with a pipette

Exposure duration: gestational day 14 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 11)

Age of measurement: gestational day 19

 Reference [PubMed Link]
Timms BG, Howdeshell KL, Barton L, Bradley S, Richter CA, vom Saal FS. 2005. Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. Proceedings of the National Academy of Sciences USA 102(19):7014-7019 and cover illustration.