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4 results for: Bisphenol A, Central Nervous System — WEEK 25

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Increased nightime hyperactivity at 4 weeks of age

Subjects: Wistar rats

Chemical: Bisphenol A

Low doses tested: 87 nmol/10 μl/rat(~10 g)

Route of administration: injected intracisternally into pups

Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26)

Age of measurement: 4 and 8 weeks of age

 Reference [PubMed Link]
Ishido M, Morita M, Oka S, Masuo Y. 2005. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept 126(1-2):145-153.
Study Results Study Details References

Results for Bisphenol A

Decreased gene expression of dopamine transporter in the midbrain

Subjects: Wistar rats

Chemical: Bisphenol A

Low doses tested: 87 nmol/10 μl/rat(~10 g)

Route of administration: injected intracisternally into pups

Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26)

Age of measurement: 4 and 8 weeks of age

 Reference [PubMed Link]
Ishido M, Morita M, Oka S, Masuo Y. 2005. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept 126(1-2):145-153.
Study Results Study Details References

Results for Bisphenol A

Increased spontaneous motor activity

Subjects: Wistar rats

Chemical: Bisphenol A

Low doses tested: 87 nmol/10 μl/rat(~10 g)

Route of administration: injected intracisternally into pups

Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26)

Age of measurement: 4 weeks of age

 Reference [PubMed Link]
Masuo Y, Morita M, Oka S, Ishido M. 2004. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: A study inspired by the physiological roles of PACAP in the brain. Regul Pept 123(1-3):225-234.
Study Results Study Details References

Results for Bisphenol A

Increased gene expression in midbrain

Subjects: Wistar rats

Chemical: Bisphenol A

Low doses tested: 87 nmol/10 μl/rat(~10 g)

Route of administration: injected intracisternally into pups

Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26)

Age of measurement: 8 weeks of age

 Reference [PubMed Link]
Masuo Y, Morita M, Oka S, Ishido M. 2004. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: A study inspired by the physiological roles of PACAP in the brain. Regul Pept 123(1-3):225-234.