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At approximately day 1

First expression of T cell receptors in the thymus.

Reference [PubMed Link]

West LJ. 2002 Sep-Oct. Defining critical windows in the development of the human immune system. Hum Exp Toxicol 21(9-10):499-505.

At approximately day 1

Lymphoid tissue develops in Peyer’s patches and the appendix by week 15.

Duration: 4 weeks

Reference [PubMed Link]

West LJ. 2002 Sep-Oct. Defining critical windows in the development of the human immune system. Hum Exp Toxicol 21(9-10):499-505.

At approximately day 1

Gene rearrangement in the developing thymocytes begins, followed by T cell receptor expression then sequential expression of coreceptors.

Reference [PubMed Link]

West LJ. 2002 Sep-Oct. Defining critical windows in the development of the human immune system. Hum Exp Toxicol 21(9-10):499-505.