Oogonial meiosis detected.
O’Rahilly R, Muller F. 2001. Human embryology & teratology. Third edition. New York: Wiley-Liss.
Oncofetal antigens and steroid receptors expressed.
Gould DA, Moscoso GJ, Young MP, Barton DP. 2000. Human first trimester fetal ovaries express oncofetal antigens and steroid receptors. J Soc Gynecol Investig 7(2):131-138.
Fetal ovary capable of synthesizing estradiol.
Duration: 2 weeks
Sizonenko PC. 1993. Sexual differentiation. In: Bertrand J, Rappaport R, Sizonenko PC, eds. Pediatric Endocrinology. Baltimore, MD: Williams & Wilkins.
Wolffian ducts begin to regress.
Duration: 2 weeks
Sizonenko PC. 1993. Sexual differentiation. In: Bertrand J, Rappaport R, Sizonenko PC, eds. Pediatric Endocrinology. Baltimore, MD: Williams & Wilkins.
The epithelium has sunk down into the mesoderm beneath the level of the adjacent ectoderm, and forms a flask-shaped structure. The developing structure is now known as a “nipple.”
Duration: 1 week
Hojo R, Zareba G, Kai JW, Baggs RB, Weiss B. 2006. Sex-specific alterations of cerebral cortical cell size in rats exposed prenatally to dioxin. J Appl Toxicol 26(1):25-34.
Mammary tissues are localized as discrete structures formed from a solid bud of cells.
Laurence DJ, Monaghan P, Gusterson, BA. 1991. The development of the normal human breast. Oxford Reviews of Reproductive Biology 13:149-174.
Steroidogenic ability of early fetal ovaries is possibly due to interstitial cells which differentiate in the medulla and do not seem to be associated with thecal cells.
Duration: 10 weeks
Rabinovici J, Jaffe RB. 1990. Development and regulation of growth and differentiated function in human and subhumand primate fetal gonads. Endocrine Reviews 11(4):532-557.