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8 results for: Bisphenol A, Other Systems — WEEK 3

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Alterations in the expression of Htra2 transcript.

Subjects: JF1xOG2 mice

Chemical: Bisphenol A

Low doses tested: 0.2 mg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered by gavage

Exposure duration: gestational day 8.5 – gestational day 12.5 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 6)

Age of measurement: gestational day 13.5

 Reference [PubMed Link]
Kang ER, Iqbal K, Tran DA, Rivas GE, Singh P, Pfeifer GP, Szabo PE. 2011. Effects of endocrine disruptors on imprinted gene expression in the mouse embryo. Epigenetics 6(7):937-950.
Study Results Study Details References

Results for Bisphenol A

Alterations in the expression of Rtl1/Rtl1as transcript.

Subjects: JF1xOG2 mice

Chemical: Bisphenol A

Low doses tested: 0.2 mg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered by gavage

Exposure duration: gestational day 8.5 – gestational day 12.5 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 6)

Age of measurement: gestational day 13.5

 Reference [PubMed Link]
Kang ER, Iqbal K, Tran DA, Rivas GE, Singh P, Pfeifer GP, Szabo PE. 2011. Effects of endocrine disruptors on imprinted gene expression in the mouse embryo. Epigenetics 6(7):937-950.
Study Results Study Details References

Results for Bisphenol A

Alterations in the expression of Nesp and Zim1 transcript.

Subjects: JF1xOG2 mice

Chemical: Bisphenol A

Low doses tested: 0.2 mg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered by gavage

Exposure duration: gestational day 8.5 – gestational day 12.5 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 6)

Age of measurement: gestational day 13.5

 Reference [PubMed Link]
Kang ER, Iqbal K, Tran DA, Rivas GE, Singh P, Pfeifer GP, Szabo PE. 2011. Effects of endocrine disruptors on imprinted gene expression in the mouse embryo. Epigenetics 6(7):937-950.
Study Results Study Details References

Results for Bisphenol A

Alterations in the expression of Tnfrs22, Rtl1/Rtl1as, and Rtl1 transcript.

Subjects: JF1xOG2 mice

Chemical: Bisphenol A

Low doses tested: 0.2 mg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered by gavage

Exposure duration: gestational day 8.5 – gestational day 12.5 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 6)

Age of measurement: gestational day 13.5

 Reference [PubMed Link]
Kang ER, Iqbal K, Tran DA, Rivas GE, Singh P, Pfeifer GP, Szabo PE. 2011. Effects of endocrine disruptors on imprinted gene expression in the mouse embryo. Epigenetics 6(7):937-950.
Study Results Study Details References

Results for Bisphenol A

Alterations in the expression of Htra2, Dhcr7, Rtl1/Rtl1as, Rtl1as and Rtl1 transcript.

Subjects: JF1xOG2 mice

Chemical: Bisphenol A

Low doses tested: 0.2 mg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered by gavage

Exposure duration: gestational day 8.5 – gestational day 12.5 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 6)

Age of measurement: gestational day 13.5

 Reference [PubMed Link]
Kang ER, Iqbal K, Tran DA, Rivas GE, Singh P, Pfeifer GP, Szabo PE. 2011. Effects of endocrine disruptors on imprinted gene expression in the mouse embryo. Epigenetics 6(7):937-950.
Study Results Study Details References

Results for Bisphenol A

Increased body weight and adipose tissue weight in females only

Subjects: ICR (CD-1) mice

Chemical: Bisphenol A

Low doses tested: 1 μg/ml

Other doses tested: 10 μg/ml (2.72 mg/kg bw/d)

Route of administration: dissolved and fed in drinking water

Exposure duration: gestational day 10 – post-natal day 30 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: 31 days of age

 Reference [PubMed Link]
Miyawaki J, Sakayama K, Kato H, Yamamoto H, Masuno H. 2007. Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice. Journal of Atherosclerosis and Thrombosis 14(5):245-252.
Study Results Study Details References

Results for Bisphenol A

Increased body weight, body fat and visceral fat in males on post-natal day 140 treated at 0.1 mg/L dose level.

Subjects: Sprague Dawley rats

Chemical: Bisphenol A

Low doses tested: 0.01, 0.1 and 1.0 mg/L

Route of administration: delivered in drinking water daily

Exposure duration: gestational day 11 – lactational day 21 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: post-natal day 42, 70 and 140

 Reference [PubMed Link]
Xu X, Tan L, Himi T, Sadamatsu M, Tsutsumi S, Akaike M, Kato N. 2011. Changed preference for sweet taste in adulthood induced by perinatal exposure to bisphenol A-A probable link to overweight and obesity. Neurotoxicol Teratol 33(4):458-463.
Study Results Study Details References

Results for Bisphenol A

Increased blood pressure in males exposed to 0.1 mg/kg on post-natal day 140.

Subjects: Sprague Dawley rats

Chemical: Bisphenol A

Low doses tested: 0.01, 0.1 and 1.0 mg/L

Route of administration: delivered in drinking water daily

Exposure duration: gestational day 11 – lactational day 21 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: post-natal day 42, 70 and 140

 Reference [PubMed Link]
Xu X, Tan L, Himi T, Sadamatsu M, Tsutsumi S, Akaike M, Kato N. 2011. Changed preference for sweet taste in adulthood induced by perinatal exposure to bisphenol A-A probable link to overweight and obesity. Neurotoxicol Teratol 33(4):458-463.