The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Phthalates (DBP)Decreased expression of genes involved in cholesterol transport and steroidogenesis
Subjects: SD rats
Chemical: Phthalates (DBP)
Low doses tested: 0.1 or 1.0 mg/kg bw/d
Other doses tested: 10, 50, 100 or 500 mg/kg bw/d
Route of administration: dissolved in corn oil and delivered through gavage
Exposure duration: gestational day 12 – gestational day 19 (comparable to human prenatal development from approximately day 1 of week 4 to day 1 of week 11)
Age of measurement: gestational day 19 (near birth)
|Reference [PubMed Link]
Lehmann KP, Phillips S, Sar M, Foster PMD, Gaido KW. 2004. Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol Sci 81(1):60-68.