The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Dioxin (TCDD)Increased frequency of cleft clitoris and vaginal thread
Subjects: Holtzman rats
Chemical: Dioxin (TCDD)
Low doses tested: 1.0 μg/kg bw
Route of administration: dissolved in corn oil and delivered through gavage
Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9)
Age of measurement: birth through adulthood
|Reference [PubMed Link]
Flaws JA, Sommer RJ, Silbergeld EK, Peterson RE, Hirshfield AN. 1997. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces genital dysmorphogenesis in the female rat. Toxicology & Applied Pharmacology 147(2):351-362.