The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Dose related decrease in earned opportunities to run, lever response rate, and total revolutions in the running wheel task |
Subjects: Holtzman rats Chemical: Dioxin (TCDD) Low doses tested: 0.02, 0.6 or 0.18 μg/kg Route of administration: dissolved in olive oil and delivered through gavage Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9) Age of measurement: birth through young adulthood |
Reference [PubMed Link] Markowski VP, Zareba G, Stern S, Cox C, Weiss B. 2001. Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 109(6):1-7. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased number of viable cells and increased number of apoptotic cortical cells from 1 day old pups. Decreased K+ evoked extracellular glutamate levels in 1, 14, and 60 day old rats. Decreased glutamate uptake in cerebral cortical cells in 14 and 60 day old rats. |
Subjects: Dark-Agouti rats Chemical: Dioxin (TCDD) Low doses tested: 0.7 μg/kg bw Route of administration: dissolved in corn oil and administered orally Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9) Age of measurement: post-natal days 1, 14 and 60 |
Reference [PubMed Link] Tomasini MC, Beggiato S, Ferraro L, Tanganelli S, Marani L, Lorenzini L, Antonelli T. 2012. Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex. Neurochem Int 61(5):759-766. |