The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased CYP1A1 mRNA levels on post-natal day 2 |
Subjects: Sprague-Dawley rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg Route of administration: delivered subcutaneously Exposure duration: post-natal day 2 – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22) Age of measurement: 70 days of age |
Reference [PubMed Link] Ohsako S, Miyabara Y, Sakaue M, Ishimura R, Kakeyama M, Izumi H, Yonemoto J, Tohyama C. 2002. Developmental stage-specific effects of perinatal 2,3,7,8- tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring. Toxicol Sci 66(2):283-292. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased percentage of eyes opened at 12 through 14 days of age |
Subjects: Line C (highly sensitive to TCDD) rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered orally Exposure duration: 2 days of age – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22) Age of measurement: 40 days of age |
Reference [PubMed Link] Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66. |